Network of vascular-associated dendritic cells in intima of healthy young individuals

Millonig,G.; Niederegger,H.; Rabl,W.; Hochleitner,B.W.; Hoefer,D.; Romani,N.; Wick,G.; In earlier studies, our group has established a new “immunological” hypothesis for atherogenesis supported by experimental and clinical studies showing that inflammatory immunological reactions against heat shock protein 60 initiate the development of atherosclerosis. In the present study, we describe the discovery of a so-far-unknown network of dendritic cells in the innermost layer of arteries, the intima, but not veins of healthy humans and rabbits. [Read More]

Online reference database of European Y-chromosomal short tandem repeat (STR) haplotypes

Roewer,L.; Krawczak,M.; Willuweit,S.; Nagy,M.; Alves,C.; Amorim,A.; Anslinger,K.; Augustin,C.; Betz,A.; Bosch,E.; Caglia,A.; Carracedo,A.; Corach,D.; Dekairelle,A.; Dobosz,T.; Dupuy,B.M.; Furedi,S.; Gehrig,C.; Gusmao,L.; Henke,J.; Henke,L.; Hidding,M.; Hohoff,C.; Hoste,B.; Jobling,M.A.; Kargel,H.J.; De Knijff,P.; Lessig,R.; Liebeherr,E.; Lorente,M.; Martinez-Jarreta,B.; Nievas,P.; Nowak,M.; Parson,W.; Pascali,V.L.; Penacino,G.; Ploski,R.; Rolf,B.; Sala,A.; Schmidt,U.; Schmitt,C.; Schneider,P.M.; Szibor,R.; Teifel-Greding,J.; Kayser,M.; The reference database of highly informative Y-chromosomal short tandem repeat (STR) haplotypes (YHRD), available online at http://ystr.charite.de, represents the largest collection of male- specific genetic profiles currently available for European populations. [Read More]

Population genetics of ten STR loci (AmpFlSTR SGM plus) in Austria

Steinlechner,M.; Berger,B.; Scheithauer,R.; Parson,W.; A population study on the ten short tandem repeat (STR) loci D3S1358, VWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, TH01 and FGA was performed on 204 unrelated Austrian Caucasians. The DNA was amplified by multiplex PCR using the AmpF/STR SGM plus kit. All loci met Hardy-Weinberg expectations. The combined power of exclusion for the ten STR loci was 0.999976. The results show that these loci are very useful for forensic purposes [Read More]

Results of a collaborative study of the EDNAP group regarding the reproducibility and robustness of the Y-chromosome STRs DYS19, DYS389 I and II, DYS390 and DYS393 in a PCR pentaplex format

Carracedo,A.; Beckmann,A.; Bengs,A.; Brinkmann,B.; Caglia,A.; Capelli,C.; Gill,P.; Gusmao,L.; Hagelberg,C.; Hohoff,C.; Hoste,B.; Kihlgren,A.; Kloosterman,A.; Myhre,Dupuy B.; Morling,N.; O’Donnell,G.; Parson,W.; Phillips,C.; Pouwels,M.; Scheithauer,R.; Schmitter,H.; Schneider,P.M.; Schumm,J.; Skitsa,I.; Stradmann-Bellinghausen,B.; Stuart,M.; Syndercombe Court; Vide,C.; A collaborative exercise was carried out by the European DNA Profiling Group (EDNAP) in the frame work of the STADNAP program, i.e. standardization of DNA profiling in Europe, in order to evaluate the performance of a Y-chromosome STR pentaplex, which includes the loci DYS19, DYS389 I and II, DYS390 and DYS393 and to determine whether uniformity of results could be achieved among different European laboratories. [Read More]