Dallinger,R.; Wang,Y.; Berger,B.; Mackay,E.A.; Kagi,J.H.; The Cd-sequestering metallothionein (MT) isoform isolated from the midgut gland of Roman snails exposed to Cd supplements in the feed was characterized by compositional and spectroscopic analysis. The preparations contained nearly 5 mol of Cd, small amounts of Cu and about 1 mol of Zn per chain mass of 6620 Da, in numerical agreement with the apoprotein’s measured capacity of firmly binding a maximum of 6 equivalents of Cd per molecule. [Read More]

Tzankov,A.; Ludescher,C.; Duba,H.C.; Steinlechner,M.; Knapp,R.; Schmid,T.; Grunewald,K.; Gastl,G.; Stauder,R.; Spontaneous remission of adult acute myelogenous leukaemia (AML) represents a rare event. We report a 60-year-old female patient suffering from secondary AML M1 and severe invasive pulmonary hyalohyphomycosis highly suggestive of aspergillosis. Two months after the diagnosis of leukaemia, she achieved a spontaneous remission lasting 3 months, although neither cytostatic drugs nor corticoids were administered because of a septic condition. At the time of remission, a chronic hepatitis C virus infection and a polyclonal hypergammaglobulinaemia were present, and the patient received granulocyte colony-stimulating factor once. [Read More]

Parson,W.; Niederstätter,H.; Kochl,S.; Steinlechner,M.; Berger,B.; Y-chromosomal short tandem repeats (Y-STRs) are useful forensic DNA markers in investigation of sexual assault cases when a mixture of male and female DNA (e.g., in vaginal swabs) is present in a sample, especially when DNA of the male contributor is present only in very small amount compared to the DNA of the female victim. With autosomal STR analysis of male and female DNA, male DNA in mixtures can usually be detected and correctly interpreted on ly when it exceeds 5%. [Read More]

Roewer,L.; Kayser,M.; De Knijff,P.; Anslinger,K.; Betz,A.; Caglia,A.; Corach,D.; Furedi,S.; Henke,L.; Hidding,M.; Kargel,H.J.; Lessig,R.; Nagy,M.; Pascali,V.L.; Parson,W.; Rolf,B.; Schmitt,C.; Szibor,R.; Teifel-Greding,J.; Krawczak,M.; A 9-locus microsatellite framework (minimal haplotype), previously developed for forensic purposes so as to facilitate stain analysis, personal identification and kinship testing, has been adopted for the establishment of a large reference database of male European Y-chromosomal haplotypes. The extent of population stratification pertaining to this database, an issue crucial for its practical forensic application, was assessed through analysis of molecular variance (AMOVA) of the 20 regional samples included. [Read More]

Parson,W.; Steinlechner,M.; Berger,B.; Mühlmann,R.; Scheithauer,R.;

Progress in Forensic Genetics 2000 8:463-466