House of the dead-exceptional burials of the Avar period (seventh century AD) in Podersdorf am See (Burgenland/A)

Tobias,B.; Waldner,T.K.; Strobl,C.; Niederstätter,H.; Musalek,C.; Saliari,K.; Töchterle,U.; Parson,W.; A unique archaeological finding of five individuals buried in an early medieval pit house was discovered in Podersdorf am See (Austria). Three of those individuals were buried in narrow grave pits that had been deepened into the house floor; two of them were lying on the pit floor in a crouched position. Pit houses with six-post construction are known since Roman times and were particularly widespread during the Migration Period. [Read More]

Immune and Neuroendocrine Trait and State Markers in Psychotic Illness: Decreased Kynurenines Marking Psychotic Exacerbations

DePicker,L.; Fransen,E.; Coppens,V.; Timmers,M.; deBoer,P.; Oberacher,H.; Fuchs,D.; Verkerk,R.; Sabbe,B.; Morrens,M.; Objective: Different patterns of immune system upregulation are present in the acute vs. post-treatment states of psychotic illness. We explored the existence of state and trait markers in the peripheral immune system and two immune-associated neuroendocrine pathways (IDO and GTP-CH1 pathway) in a longitudinal sample of psychosis patients. We also evaluated the association of these markers with neuropsychiatric symptomatology. Method: Plasma concentrations of peripheral blood markers were measured in a transdiagnostic group of 49 inpatients with acute psychosis and 52 matched healthy control subjects. [Read More]

Impact of the sequencing method on the detection and interpretation of mitochondrial DNA length heteroplasmy

Sturk-Andreaggi,K.; Parson,W.; Allen,M.; Marshall,C.; Advancements in sequencing technologies allow for rapid and efficient analysis of mitochondrial DNA (mtDNA) in forensic laboratories, which is particularly beneficial for specimens with limited nuclear DNA. Next generation sequencing (NGS) offers higher throughput and sensitivity over traditional Sanger-type sequencing (STS) as well as the ability to quantitatively analyze the data. Changes in sample preparation, sequencing method and analysis required for NGS may alter the mtDNA haplotypes compared to previously generated STS data. [Read More]

Inter-laboratory study on standardized MPS libraries: evaluation of performance, concordance, and sensitivity using mixtures and degraded DNA

Müller,P.; Sell,C.; Hadrys,T.; Hedman,J.; Bredemeyer,S.; Laurent,F.X.; Roewer,L.; Achtruth,S.; Sidstedt,M.; Sijen,T.; Trimborn,M.; Weiler,N.; Willuweit,S.; Bastisch,I.; Parson,W.; SeqForSTRConsortium; We present results from an inter-laboratory massively parallel sequencing (MPS) study in the framework of the SeqForSTRs project to evaluate forensically relevant parameters, such as performance, concordance, and sensitivity, using a standardized sequencing library including reference material, mixtures, and ancient DNA samples. The standardized library was prepared using the ForenSeq DNA Signature Prep Kit (primer mix A). [Read More]