Age dependent apoptosis and loss of rhabdosphincter cells [In Process Citation]

Strasser,H.; Tiefenthaler,M.; Steinlechner,M.; Eder,I.; Bartsch,G.; Konwalinka,G.; PURPOSE: To our knowledge the exact age dependent morphological and functional changes of the sphincter mechanism have not been investigated. Therefore, cell densities of the urethra and the urethral rhabdosphincter across various age groups, and the appearance of apoptosis were examined to explore the changes in these structures during the aging process. MATERIALS AND METHODS: Specimens were obtained from 16 male and 7 female cadavers 5 weeks to 92 years old. [Read More]

Is it possible to differentiate mtDNA by means of HVIII in samples that cannot be distinguished by sequencing the HVI and HVII regions?

Lutz,S.; Wittig,H.; Weisser,H.; Heizmann,J.; Junge,A.; mo-Simonin,N.; Parson,W.; Edelmann,J.; Anslinger,K.; Jung,S.; Augustin,C.; The mitochondrial control region includes three so-called hypervariable (HV) regions, in which the polymorphic positions show a particularly high frequency. According to a population study of 200 unrelated individuals from Germany, HVI (positions 16,024-16,365, according to Anderson) showed 88 variable positions in a total length of 342 bp (26%) and HVII (positions 73-340) displayed 65 mutable sites in 268 bp (24%). [Read More]

Isolation and characterization of a self-sufficient one-domain protein. (Cd)-metallothionein from Eisenia foetida

Gruber,C.; Sturzenbaum,S.; Gehrig,P.; Sack,R.; Hunziker,P.; Berger,B.; Dallinger,R.; Earthworms have been shown to accumulate trace elements in general, and particularly high amounts of metal ions such as cadmium, copper and zinc. The earthworm’s response to metal contamination has been linked to the induction and expression of metallothionein (MT) proteins, a detoxification strategy analogous to that found in other biological systems. The present study focuses on an inducible Cd-MT isolated from the compost-dwelling brandling worm Eisenia foetida (Savigny). [Read More]