Mann,C.J.; Anderson,T.A.; Read,J.; Chester,S.A.; Harrison,G.B.; Kochl,S.; Ritchie,P.J.; Bradbury,P.; Hussain,F.S.; Amey,J.; Vanloo,B.; Rosseneu,M.; Infante,R.; Hancock,J.M.; Levitt,D.G.; Banaszak,L.J.; Scott,J.; Shoulders,C.C.; The assembly of atherogenic lipoproteins requires the formation in the endoplasmic reticulum of a complex between apolipoprotein (apo)B, a microsomal triglyceride transfer protein (MTP) and protein disulphide isomerase (PDI). Here we show by molecular modelling and mutagenesis that the globular amino-terminal regions of apoB and MTP are closely related in structure to the ancient egg yolk storage protein, vitellogenin (VTG). [Read More]

Strasser,H.; Tiefenthaler,M.; Steinlechner,M.; Bartsch,G.; Konwalinka,G.;

With advancing age, a progressive and age-dependent decrease of the density of striated muscle cells can be observed in the rhabdosphincter. This continuous loss of striated muscle cells due to apoptosis may finally lead to urinary incontinence

Lancet 1999 354(9182):918-919

Waltner-Romen,M.; Falkensammer,G.; Rabl,W.; Wick,G.; In recent years our laboratory has developed an immunological hypothesis for the pathogenesis of atherosclerosis. We have shown that cellular and humoral immune reactions against heat shock proteins (Hsps) 60/65 expressed on the surface of stressed endothelial cells comprise the initial event in the pathogenesis of this disease. In the course of these studies, we also investigated normal, unaffected arteries for control purposes (carotid bifurcations from children aged 8 weeks to 10 years). [Read More]

Bonatti,J.; Ladurner,R.; Hangler,H.; Katzgraber,F.; OBJECTIVE: Minimally invasive multiple vessel revascularization has been accomplished using all arterial graft concepts and aortocoronary vein grafts. The aim of the present study was to determine the technical feasibility of minimally invasive axillary artery to coronary artery vein grafting in the human cadaver. METHODS: In seven human cadavers the axillary artery was approached bilaterally via a small incision above the anterior axillary fold. The left anterior descending coronary artery system and the right coronary artery system were exposed via a left anterior minithoracotomy and a subxiphoid incision respectively. [Read More]

Schiller,C.; Gruber,R.; Ho,G.M.; Redlich,K.; Gober,H.J.; Katzgraber,F.; Willheim,M.; Hoffmann,O.; Pietschmann,P.; Peterlik,M.; In mouse bone marrow cultures, the formation of osteoclast-like, that is, tartrate-resistant acid phosphatase-positive (TRAP+) and calcitonin (CT) receptor-positive multinucleated cells (MNCs), induced by 10(-10) to 10(-8) mol/L 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3], could be augmented by triiodothyronine (T3), which alone had no effect on osteoclast-like cell formation. The permissive effect of T3 increased the response to 1alpha,25(OH)2D3 by approximately one order of magnitude. [Read More]