Cerebrospinal Fluid Drug Concentrations and Clinical Outcome of Patients with Neoplastic Meningitis Treated with Liposomal Cytarabine

Bohn,J.P.; Reinstadler,V.; Pall,G.; Stockhammer,G.; Steurer,M.; Oberacher,H.; Wolf,D.; BACKGROUND AND OBJECTIVE: Liposomal cytarabine is a slow-release formulation for intrathecal application in patients with neoplastic meningitis. Although standard dosing intervals range from 2 to 4 weeks, it is unclear whether sustained cytotoxic cerebrospinal fluid (CSF) concentrations can be achieved beyond 14 days from drug injection. The objective of this study was to assess CSF and plasma concentrations of liposomal cytarabine more than 2 weeks after lumbar drug administration and to correlate those findings with clinical outcome. [Read More]

Das frühmittelalterliche Gräberfeld von Podersdorf am See (Burgenland, Ostösterreich) Veränderung der Bestattungssitten im diachronen Vergleich

Tobias,B.,; Saliari,K.; Draganits,E.; Musalek,C.; Wiltschke-Schrotta,K.; Waldner,T.; Totschnig,R.; Strobl,C.; Niederstätter,H.; Parson,W.; Skomorowski,R.; Löcker,K.; In dieser Arbeit wird das frühmittelalterliche Gräberfeld von Podersdorf erstmals in seinem landschaftsarchäologischen, diachronen Kontext präsentiert. Die verwendeten interdisziplinären Methoden zeigen das Gräberfeld in einem unerwartet dichten räumlichen Zusammenhang mit weiteren Gräberfeldern, Siedlungen und Straßen, die sich zeitlich von der römischen Kaiserzeit über die Völkerwanderungszeit bis zum Hochmittelalter erstrecken. Am Fallbeispiel des frühmittelalterlichen Gräberfeldes von Podersdorf am See wird die Veränderung gewisser Bestattungssitten im Lauf des 1. [Read More]

DNA Testing Reveals the Putative Identity of JB55, a 19th Century Vampire Buried in Griswold, Connecticut

Daniels-Higginbotham,J.; Gorden,E.M.; Farmer,S.K.; Spatola,B.; Damann,F.; Bellantoni,N.; Gagnon,K.S.; delaPuente,M.; Xavier,C.; Walsh,S.; Parson,W.; McMahon,T.P.; Marshall,C.; In 1990 in Griswold, Connecticut, archaeologists excavated a burial found in a “skull and crossbones” orientation. The lid of the 19th century coffin had brass tacks that spelled “JB55”, the initials of the person lying there and age at death. JB55 had evidence of chronic pulmonary infection, perhaps tuberculosis. It is possible that JB55 was deemed a vampire due to his disease, and therefore had to be “killed” by mutilating his corpse. [Read More]

Evaluation of mitogenome sequence concordance, heteroplasmy detection, and haplogrouping in a worldwide lineage study using the Precision ID mtDNA Whole Genome Panel

Strobl,C.; ChurchillCihlar,J.; Lagace,R.; Wootton,S.; Roth,C.; Huber,N.; Schnaller,L.; Zimmermann,B.; Huber,G.; LayHong,S.; Moura-Neto,R.; Silva,R.; Alshamali,F.; Souto,L.; Anslinger,K.; Egyed,B.; Jankova-Ajanovska,R.; Casas-Vargas,A.; Usaquen,W.; Silva,D.; Barletta-Carrillo,C.; Tineo,D.H.; Vullo,C.; Würzner,R.; Xavier,C.; Gusmao,L.; Niederstätter,H.; Bodner,M.; Budowle,B.; Parson,W.; The emergence of Massively Parallel Sequencing technologies enabled the analysis of full mitochondrial (mt)DNA sequences from forensically relevant samples that have, so far, only been typed in the control region or its hypervariable segments. In this study, we evaluated the performance of a commercially available multiplex-PCR-based assay, the Precision ID mtDNA Whole Genome Panel (Thermo Fisher Scientific), for the amplification and sequencing of the entire mitochondrial genome (mitogenome) from even degraded forensic specimens. [Read More]

Forensic characterization and statistical considerations of the CaDNAP 13-STR panel in 1,184 domestic dogs from Germany, Austria, and Switzerland

Berger,B.; Heinrich,J.; Niederstätter,H.; Hecht,W.; Morf,N.; Hellmann,A.; Rohleder,U.; Schleenbecker,U.; Berger,C.; Parson,W.; CaDnapGroup; Crime scene samples originating from domestic dogs such as hair, blood, or saliva can be probative as possible transfer evidence in human crime and in dog attack cases. In the majority of such cases canine DNA identification using short tandem repeat (STR) analysis is the method of choice, which demands, among others, a systematic survey of allele frequency data in the relevant dog populations. [Read More]