Oberacher,H.; Arnhard,K.; Untargeted LC-MS/MS techniques have become indispensable tools for systematic toxicological analysis. Compound identification is based on the mass spectrometric information obtained, and this may include m/z, isotopic pattern, retention time and fragmentation information. All these different kinds of analytical features can be stored in libraries and databases. Currently, the most competent approach for compound identification involves tandem mass spectral library search. State-of-the-art databases were shown to be sensitive, specific, robust and instrument-independent. [Read More]

Klieber,M.; Oberacher,H.; Hofstaetter,S.; Beer,B.; Neururer,M.; Amann,A.; Alber,H.; Modak,A.; The phenotype pantoprazole-(13)C breath test (Ptz-BT) was used to evaluate the extent of phenoconversion of CYP2C19 enzyme activity caused by commonly prescribed proton pump inhibitors (PPI) omeprazole and esomprazole. The Ptz-BT was administered to 26 healthy volunteers and 8 stable cardiovascular patients twice at baseline and after 28 days of PPI therapy to evaluate reproducibility of the Ptz-BT and changes in CYP2C19 enzyme activity (phenoconversion) after PPI therapy. [Read More]

Haldemann,B.; Dornseifer,S.; Heylen,T.; Aelbrecht,C.; Bleka,O.; Larsen,H.J.; Willuweit,S.; Alonso,A.; Teodoridis,J.M.; Morzfeld,J.; Zatkalikova,L.; Krupsky,M.; Berger,B.; Parson,W.; Morling,N.; Gill,P.; Neuhaus-Steinmetz,U.;

eDNA is an expert software system for DNA profile comparison, match interpretation and automated report generation in forensic DNA casework. Process automation and intelligent graphical representation maximise reliability of DNA evidence, while facilitating and accelerating the work of DNA experts.

Forensic Science International: Genetics Supplement Series 2015 5:e400-e402

Karakostas,N.; Kaloudi-Chantzea,A.; Martinou,E.; Seintis,K.; Pitterl,F.; Oberacher,H.; Fakis,M.; Kallitsis,J.K.; Pistolis,G.; We herein present the coordination-driven supramolecular synthesis and photophysics of a [4+4] and a [2+2] assembly, built up by alternately collocated donor-acceptor chromophoric building blocks based, respectively, on the boron dipyrromethane (Bodipy) and perylene bisimide dye (PBI). In these multichromophoric scaffolds, the intensely absorbing/emitting dipoles of the Bodipy subunit are, by construction, cyclically arranged at the corners and aligned perpendicular to the plane formed by the closed polygonal chain comprising the PBI units. [Read More]

Marcinska,M.; Pospiech,E.; Abidi,S.; Andersen,J.D.; vandenBerge,M.; Carracedo,A.; Eduardoff,M.; Marczakiewicz-Lustig,A.; Morling,N.; Sijen,T.; Skowron,M.; Sochtig,J.; Syndercombe-Court,D.; Weiler,N.; Schneider,P.M.; Ballard,D.; Borsting,C.; Parson,W.; Phillips,C.; Branicki,W.; Euroforgen-NoeConsortium; Androgenetic alopecia, known in men as male pattern baldness (MPB), is a very conspicuous condition that is particularly frequent among European men and thus contributes markedly to variation in physical appearance traits amongst Europeans. Recent studies have revealed multiple genes and polymorphisms to be associated with susceptibility to MPB. In this study, 50 candidate SNPs for androgenetic alopecia were analyzed in order to verify their potential to predict MPB. [Read More]