Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study

Beer,B.; Erb,R.; Pavlic,M.; Ulmer,H.; Giacomuzzi,S.; Riemer,Y.; Oberacher,H.; It is becoming increasingly evident that genetic variants contribute to the development of opioid addiction. An elucidation of these genetic factors is crucial for a better understanding of this chronic disease and may help to develop novel therapeutic strategies. In recent years, several candidate genes were implicated in opioid dependence. However, most study findings have not been replicated and additional studies are required before reported associations can be considered robust. [Read More]

Bright ambient light conditions reduce the effect of tryptophan depletion in healthy females

Defrancesco,M.; Niederstätter,H.; Parson,W.; Kemmler,G.; Hinterhuber,H.; Marksteiner,J.; Deisenhammer,E.A.; INTRODUCTION: Tryptophan depletion (TD) is an established method to influence the serotonergic system and mood. The purpose of this study was to examine the effect of TD under different ambient light conditions, measured through serotonin-associated plasma levels and a visual analog scale (VAS), on healthy females. METHODS: Thirty-eight healthy female s-allele carriers of the serotonin transporter promoter gene (5-HTTLPR) were administered a TD under dim light conditions (75 lx). [Read More]

Can clinical CT data improve forensic reconstruction?

Schuh,P.; Scheurer,E.; Fritz,K.; Pavlic,M.; Hassler,E.; Rienmuller,R.; Yen,K.; In accidents resulting in severe injuries, a clinical forensic examination is generally abandoned in the initial phase due to high-priority clinical needs. However, in many cases, data from clinical computed tomography (CT) examinations are available. The goals of this prospective study were (a) to evaluate clinical CT data as a basis for forensic reconstruction of the sequence of events, (b) to assess if forensic radiological follow-up reading improves the forensic diagnostic benefit compared to the written clinical radiological reports, and (c) to evaluate if full data storage including additional reconstructed 0. [Read More]