Characterization of mitochondrial DNA control region lineages in Iraq

 Published in 2013

Al-Zahery,N.; Saunier,J.; Ellingson,K.; Parson,W.; Parsons,T.J.; Irwin,J.A.; To evaluate the utility of mtDNA control region data for the purposes of forensic DNA testing in Iraq, a sample of 182 subjects (128 Arab Muslims, 15 Kurd Muslims, 22 Assyrian Christians and 17 Mandaean Arabs) was tested. High numbers of singleton haplotypes were observed among Arabs, Kurds and Assyrians, but fewer were found in Mandaeans. High molecular diversity and low random match probabilities confirmed the value of control region data in the investigation of maternal genetic lineages among the Iraqi population [Read More]

Chimerism in DNA of buccal swabs from recipients after allogeneic hematopoietic stem cell transplantations: implications for forensic DNA testing

 Published in 2013

Berger,B.; Parson,R.; Clausen,J.; Berger,C.; Nachbaur,D.; Parson,W.; We attempted to quantitatively determine the chimeric state in a total of 162 buccal swabs from 77 adult recipients aged 19-74 (median 50 years) after allogeneic hematopoietic cell transplantation by estimating the chimeric recipient/donor DNA ratios through analysis of 15 autosomal short tandem repeat markers. From each individual between one and nine, buccal swabs were taken at known time intervals after transplantation, ranging from 17 to 3,361 days (median 394 days). [Read More]

Comparison of morphological and molecular genetic sex-typing on mediaeval human skeletal remains

 Published in 2013

Bauer,C.M.; Niederstätter,H.; McGlynn,G.; Stadler,H.; Parson,W.; Archaeological excavations conducted at an early mediaeval cemetery in Volders (Tyrol, Austria) produced 141 complete skeletal remains dated between the 5th/6th and 12th/13th centuries. These skeletons represent one of the largest historical series of human remains ever discovered in the East Alpine region. Little historical information is available for this region and time period. The good state of preservation of these bioarchaeological finds offered the opportunity of performing molecular genetic investigations. [Read More]

Comparison of NIR chemical imaging with conventional NIR, Raman and ATR-IR spectroscopy for quantification of furosemide crystal polymorphs in ternary powder mixtures

 Published in 2013

Schönbichler,S.A.; Bittner,L.K.; Weiss,A.K.; Griesser,U.J.; Pallua,J.D.; Huck,C.W.; The aim of this study was to evaluate the ability of near-infrared chemical imaging (NIR-CI), near-infrared (NIR), Raman and attenuated-total-reflectance infrared (ATR-IR) spectroscopy to quantify three polymorphic forms (I, II, III) of furosemide in ternary powder mixtures. For this purpose, partial least-squares (PLS) regression models were developed, and different data preprocessing algorithms such as normalization, standard normal variate (SNV), multiplicative scatter correction (MSC) and 1st to 3rd derivatives were applied to reduce the influence of systematic disturbances. [Read More]