Pallua,J.D.; Schaefer,G.; Seifarth,C.; Becker,M.; Meding,S.; Rauser,S.; Walch,A.; Handler,M.; Netzer,M.; Popovscaia,M.; Osl,M.; Baumgartner,C.; Lindner,H.; Kremser,L.; Sarg,B.; Bartsch,G.; Huck,C.W.; Bonn,G.K.; Klocker,H.; New biomarkers are needed to improve the specificity of prostate cancer detection and characterisation of individual tumors. In a proteomics profiling approach using MALDI-MS tissue imaging on frozen tissue sections, we identified discriminating masses. Imaging analysis of cancer, non-malignant benign epithelium and stromal areas of 15 prostatectomy specimens in a test and 10 in a validation set identified characteristic m/z peaks for each tissue type, e. [Read More]

Eduardoff,M.; Huber,G.; Bayer,B.; Schmid,D.; Anslinger,K.; Gobel,T.; Zimmermann,B.; Schneider,P.M.; Röck,A.W.; Parson,W.; In forensic genetics mitochondrial DNA (mtDNA) is usually analyzed by direct Sanger-type sequencing (STS). This method is known to be laborious and sometimes prone to human error. Alternative methods have been proposed that lead to faster results. Among these are methods that involve mass-spectrometry resulting in base composition profiles that are, by definition, less informative than the full nucleotide sequence. Here, we applied a highly automated electrospray ionization mass spectrometry (ESI-MS) system (PLEX-ID) to an mtDNA population study to compare its performance with respect to throughput and concordance to STS. [Read More]

Parson,W.;

• 2013*

Bauer,C.M.; Bodner,M.; Niederstätter,H.; Niederwieser,D.; Huber,G.; Hatzer-Grubwieser,P.; Holubar,K.; Parson,W.; The successful marriage policy of margrave Leopold III increased the importance of the House of Babenberg in late medieval Austria (12th century). Historical documentation is inconclusive in providing evidence whether or not his eldest son Adalbert derived from an earlier relationship or from the marriage with King Henry IV’s daughter Agnes of Waiblingen, with whom Leopold is considered to have had 17 children. [Read More]

Niederstätter,H.; Berger,B.; Erhart,D.; Willuweit,S.; Geppert,M.; Gassner,C.; Schennach,H.; Parson,W.; Roewer,L.; The male-specific region of the human Y chromosome (MSY) is passed down clonally from father to son and mutation is the single driving force for Y-chromosomal diversification. The geographical distribution of MSY variation is non-random. Therefore, Y-chromosomal single nucleotide polymorphisms (Y-SNPs) are of forensic interest, as they can be utilized, e.g. for deducing the bio-geographical origin of biological evidence. This extra information can complement short tandem repeat data in criminal investigations. [Read More]