Oberacher,H.; Pitterl,F.; Siapi,E.; Steele,B.R.; Letzel,T.; Grosse,S.; Poschner,B.; Tagliaro,F.; Gottardo,R.; Chacko,S.A.; Josephs,J.L.; Mass spectral libraries represent versatile tools for the identification of small bioorganic molecules. Libraries based on electron impact spectra are rated robust and transferable. Tandem mass spectral libraries are often considered to work properly only on the instrument that has been used to build the library. An exception from that rule is the ‘Wiley Registry of Tandem Mass Spectral Data, MSforID’. [Read More]

Niederstätter,H.; Rampl,G.; Erhart,D.; Pitterl,F.; Oberacher,H.; Neuhuber,F.; Hausner,I.; Gassner,C.; Schennach,H.; Berger,B.; Parson,W.; The small alpine district of East Tyrol (Austria) has an exceptional demographic history. It was contemporaneously inhabited by members of the Romance, the Slavic and the Germanic language groups for centuries. Since the Late Middle Ages, however, the population of the principally agrarian-oriented area is solely Germanic speaking. Historic facts about East Tyrol’s colonization are rare, but spatial density-distribution analysis based on the etymology of place-names has facilitated accurate spatial mapping of the various language groups’ former settlement regions. [Read More]

Erb,R.; Leithner,K.; Bernkop-Schnurch,A.; Oberacher,H.; Phosporothioate oligonucleotides represent an important class of therapeutic oligonucleotides, in which none-bridging oxygen atoms of the phosphate groups are replaced by sulfur. These oligonucleotides are designed to treat disease by modulating gene expression of an affected individual. As the development and application of these therapeutical oligonucleotides require analytical support, the development, validation, and application of an assay for the quantitative analysis of a phosporothioate oligonucleotide in rat plasma is described. [Read More]

Bodner,M.; Perego,U.A.; Huber,G.; Fendt,L.; Röck,A.W.; Zimmermann,B.; Olivieri,A.; Gomez-Carballa,A.; Lancioni,H.; Angerhofer,N.; Bobillo,M.C.; Corach,D.; Woodward,S.R.; Salas,A.; Achilli,A.; Torroni,A.; Bandelt,H.J.; Parson,W.; It is now widely agreed that the Native American founders originated from a Beringian source population approximately 15-18 thousand years ago (kya) and rapidly populated all of the New World, probably mainly following the Pacific coastal route. However, details about the migration into the Americas and the routes pursued on the continent still remain unresolved, despite numerous genetic, archaeological, and linguistic investigations. [Read More]

Haas,C.; Hanson,E.; Anjos,M.J.; Bär,W.; Banemann,R.; Berti,A.; Borges,E.; Bouakaze,C.; Carracedo,A.; Carvalho,M.; Castella,V.; Choma,A.; De,Cock G.; Dotsch,M.; Hoff-Olsen,P.; Johansen,P.; Kohlmeier,F.; Lindenbergh,P.A.; Ludes,B.; Maronas,O.; Moore,D.; Morerod,M.L.; Morling,N.; Niederstätter,H.; Noel,F.; Parson,W.; Patel,G.; Popielarz,C.; Salata,E.; Schneider,P.M.; Sijen,T.; Sviezena,B.; Turanska,M.; Zatkalikova,L.; Ballantyne,J.; A second collaborative exercise on RNA/DNA co-analysis for body fluid identification and STR profiling was organized by the European DNA Profiling Group (EDNAP). Six human blood stains, two blood dilution series (5-0.001mul blood) and, optionally, bona fide or mock casework samples of human or non-human origin were analyzed by the participating laboratories using a RNA/DNA co-extraction or solely RNA extraction method. [Read More]