Santer,F.R.; Höschele,P.P.; Oh,S.J.; Erb,H.H.; Bouchal,J.; Cavarretta,I.T.; Parson,W.; Meyers,D.J.; Cole,P.A.; Culig,Z.; Inhibitors of histone deacetylases have been approved for clinical application in cancer treatment. On the other hand, histone acetyltransferase (HAT) inhibitors have been less extensively investigated for their potential use in cancer therapy. In prostate cancer, the HATs and coactivators p300 and CBP are upregulated and may induce transcription of androgen receptor (AR)-responsive genes, even in the absence or presence of low levels of AR. [Read More]

Bodner,M.; Irwin,J.A.; Coble,M.D.; Parson,W.; Reliable data are crucial for all research fields applying mitochondrial DNA (mtDNA) as a genetic marker. Quality control measures have been introduced to ensure the highest standards in sequence data generation, validation and a posteriori inspection. A phylogenetic alignment strategy has been widely accepted as a prerequisite for data comparability and database searches, for forensic applications, for reconstructions of human migrations and for correct interpretation of mtDNA mutations in medical genetics. [Read More]

Oberguggenberger,A.; Hubalek,M.; Sztankay,M.; Meraner,V.; Beer,B.; Oberacher,H.; Giesinger,J.; Kemmler,G.; Egle,D.; Gamper,E.M.; Sperner-Unterweger,B.; Holzner,B.; Adjuvant endocrine treatment-related adverse effects have a strong impact on patients’ quality of life and thereby limit therapy’s risk benefit ratio resulting in morbidity and treatment discontinuation. Still, many AI adverse effects remain untreated given that they are unrecognized by conservative methods (e.g., proxy ratings). The ability of complementary patient-reported outcomes (PROs) to provide a more comprehensive assessment of side-effects is to be explored. [Read More]

Linacre,A.; Gusmao,L.; Hecht,W.; Hellmann,A.P.; Mayr,W.R.; Parson,W.; Prinz,M.; Schneider,P.M.; Morling,N.; The use of non-human DNA typing in forensic science investigations, and specifically that from animal DNA, is ever increasing. The term animal DNA in this document refers to animal species encountered in a forensic science examination but does not include human DNA. Non-human DNA may either be: the trade and possession of a species, or products derived from a species, which is contrary to legislation; as evidence where the crime is against a person or property; instances of animal cruelty; or where the animal is the offender. [Read More]

Haas,C.; Hanson,E.; Bär,W.; Banemann,R.; Bento,A.M.; Berti,A.; Borges,E.; Bouakaze,C.; Carracedo,A.; Carvalho,M.; Choma,A.; Dotsch,M.; Duriancikova,M.; Hoff-Olsen,P.; Hohoff,C.; Johansen,P.; Lindenbergh,P.A.; Loddenkotter,B.; Ludes,B.; Maronas,O.; Morling,N.; Niederstätter,H.; Parson,W.; Patel,G.; Popielarz,C.; Salata,E.; Schneider,P.M.; Sijen,T.; Sviezena,B.; Zatkalikova,L.; Ballantyne,J.; A collaborative exercise on mRNA profiling for the identification of blood was organized by the European DNA Profiling Group (EDNAP). Seven blood samples and one blood dilution series were analyzed by the participating laboratories for the reportedly blood-specific markers HBB, SPTB and PBGD, using different kits, chemistries and instrumentation. [Read More]