Beer,B.; Rabl,W.; Libiseller,K.; Giacomuzzi,S.; Riemer,Y.; Pavlic,M.; A well-established possibility to treat opiate addiction is the participation in opiate maintenance treatment programmes. For this purpose the opioids methadone and buprenorphine have been evaluated and are used nowadays in many countries. However, since 1998 also the use of slow-release oral morphine (SROM) has been legally permitted in Austria. Our data show that these morphine preparations are frequently abused and are dominating the black market in the meantime. [Read More]

Pitterl,F.; Schmidt,K.; Huber,G.; Zimmermann,B.; Delport,R.; Amory,S.; Ludes,B.; Oberacher,H.; Parson,W.; Short tandem repeat (STR) typing has become the standard technique in forensic methodology for the identification of unknown samples. National DNA databases have been established that contain STR genotypes for intelligence purposes. Due to their success, national DNA databases have been growing so fast that the number of advantageous matches may become a logistic problem for the analysts. This is especially true for partial STR profiles as they display reduced discrimination power. [Read More]

Corach,D.; Lao,O.; Bobillo,C.; van Der,Gaag K.; Zuniga,S.; Vermeulen,M.; van,Duijn K.; Goedbloed,M.; Vallone,P.M.; Parson,W.; De Knijff,P.; Kayser,M.; We investigated the bio-geographic ancestry of Argentineans, and quantified their genetic admixture, analyzing 246 unrelated male individuals from eight provinces of three Argentinean regions using ancestry-sensitive DNA markers (ASDM) from autosomal, Y and mitochondrial chromosomes. Our results demonstrate that European, Native American and African ancestry components were detectable in the contemporary Argentineans, the amounts depending on the genetic system applied, exhibiting large inter-individual heterogeneity. [Read More]

Pitterl,F.; Erb,R.; Plattner,S.; Chevret,J.-P.; Oberacher,H.;

Proceedings of the 58th ASMS Conference on Mass Spectrometry 2010

Weiskopf,D.; Schwanninger,A.; Weinberger,B.; Almanzar,G.; Parson,W.; Buus,S.; Lindner,H.; Grubeck-Loebenstein,B.; APCs operate frequently under oxidative stress induced by aging, tissue damage, pathogens, or inflammatory responses. Phagocytic cells produce peroxides and free-radical species that facilitate pathogen clearance and can in the case of APCs, also lead to oxidative modifications of antigenic proteins and peptides. Little information is available presently about the consequences of such modifications on the immune response. To model oxidative modification of an immunodominant antigenic peptide, we oxidized the methionine residue of the human CMV pp65(495-503) (NLVPMVATV) peptide. [Read More]