Piccinini,A.; Coco,S.; Parson,W.; Cattaneo,C.; Gaudio,D.; Barbazza,R.; Galassi,A.; We report the results of an attempt to identify the supposed remains of a famous World War I (WWI) Italian soldier who was killed in battle along the Italian front in 1915. Thanks to the availability of offspring from both paternal and maternal lineage Y-STRs and mtDNA were analysed and both showed a clear exclusion scenario: the remains did not belong to the supposed war hero. [Read More]

Lu,T.T.; Lao,O.; Nothnagel,M.; Junge,O.; Freitag-Wolf,S.; Caliebe,A.; Balascakova,M.; Bertranpetit,J.; Bindoff,L.A.; Comas,D.; Holmlund,G.; Kouvatsi,A.; Macek,M.; Mollet,I.; Nielsen,F.; Parson,W.; Palo,J.; Ploski,R.; Sajantila,A.; Tagliabracci,A.; Gether,U.; Werge,T.; Rivadeneira,F.; Hofman,A.; Uitterlinden,A.G.; Gieger,C.; Wichmann,H.E.; Ruether,A.; Schreiber,S.; Becker,C.; Nurnberg,P.; Nelson,M.R.; Kayser,M.; Krawczak,M.; Genetic matching potentially provides a means to alleviate the effects of incomplete Mendelian randomization in population-based gene-disease association studies. We therefore evaluated the genetic-matched pair study design on the basis of genome-wide SNP data (309 790 markers; Affymetrix GeneChip Human Mapping 500K Array) from 2457 individuals, sampled at 23 different recruitment sites across Europe. [Read More]

Mikkelsen,M.; Rockenbauer,E.; Wächter,A.; Fend,F.; Zimmermann,B.; Parson,W.; Abel Nielsen,S.; Gilbert,T.; Willerslev,E.; Morling,N.; The GS FLX pyrosequencing platform using parallel tagged sequencing was tested on 10 Somali individuals for sequencing of the complete mitochondrial genome. The amplicons were sequenced twice with increasing coverage to establish the minimum of coverage needed to produce reliable sequence reads. The genome sequences were compared to previously obtained control regions sequences with Sanger sequencing and 49 SNPs in coding regions of the mitochondrial genome. [Read More]

Giacomuzzi,S.M.; Riemer,Y.; Pavlic,M.; Schmid,A.; Hinterhuber,H.; Amann,A.;

Subst.Use Misuse 2009 44(2):301-304
PubMed: 19142826

Parson,W.; Die Analyse der mitochondrialen DNA (mtDNA) stellt in der Forensik eine technologische Nische dar, die vor allem bei Vorliegen von qualitativ und quantitativ geringen Spuren wertvolle Hinweise für die Klärung der Spurenlegerschaft bringen kann. Das mitochondriale Erbgut liegt in den Mitochondrien jeder Zelle in hunderten bis tausenden Kopien vor, ist stabil gegenüber Degradation und wird maternal vererbt. Deshalb eignet sich die mtDNA besonders für paläogenetische Analysen und für die Rekonstruktion der Evolutionsgeschichte des Menschen. [Read More]