Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults

Schwanninger,A.; Weinberger,B.; Weiskopf,D.; Herndler-Brandstetter,D.; Reitinger,S.; Gassner,C.; Schennach,H.; Parson,W.; Wurzner,R.; Grubeck-Loebenstein,B.; ABSTRACT: Old age is associated with characteristic changes of the immune system contributing to higher incidence and severity of many infectious diseases. Particularly within the T cell compartment latent infection with human Cytomegalovirus (CMV) is contributing to and accelerating immunosenescence. However, latent CMV infection and reactivation usually does not cause overt symptoms in immunocompetent elderly persons indicating immunological control of disease. [Read More]

Analysis of forensically used autosomal short tandem repeat markers in Polish and neighboring populations

Soltyszewski,I.; Plocienniczak,A.; Fabricius,H.A.; Kornienko,I.; Vodolazhsky,D.; Parson,W.; Hradil,R.; Schmitter,H.; Ivanov,P.; Kuzniar,P.; Malyarchuk,B.A.; Grzybowski,T.; Wozniak,M.; Henke,J.; Henke,L.; Olkhovets,S.; Voitenko,V.; Lagus,V.; Ficek,A.; Minarik,G.; de,Knijff P.; Rebala,K.; Wysocka,J.; Kapinska,E.; Cybulska,L.; Mikulich,A.I.; Tsybovsky,I.S.; Szczerkowska,Z.; Krajewski,P.; Ploski,R.; The purpose of this study was to evaluate the homogeneity of Polish populations with respect to STRs chosen as core markers of the Polish Forensic National DNA Intelligence Database, and to provide reference allele frequencies and to explore the genetic interrelationship between Poland and neighboring countries. [Read More]

Avalanche accidents

Rabl,W.; Pavlic,M.; Sumann,G.;

Rechtsmedizin 2008 18(5):397-404

Comparison of five DNA quantification methods

Nielsen,K.; Mogensen,H.S.; Hedman,J.; Niederstätter,H.; Parson,W.; Morling,N.; Six commercial preparations of human genomic DNA were quantified using five quantification methods: UV spectrometry, SYBR-Green dye staining, slot blot hybridization with the probe D17Z1, Quantifiler Human DNA Quantification kit and RB1 rt-PCR. All methods measured higher DNA concentrations than expected based on the information by the manufacturers. UV spectrometry, SYBR-Green dye staining, slot blot and RB1 rt-PCR gave 39, 27, 11 and 12%, respectively, higher concentrations than expected based on the manufacturers’ information. [Read More]