Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults
Schwanninger,A.; Weinberger,B.; Weiskopf,D.; Herndler-Brandstetter,D.; Reitinger,S.; Gassner,C.; Schennach,H.; Parson,W.; Wurzner,R.; Grubeck-Loebenstein,B.;
ABSTRACT: Old age is associated with characteristic changes of the immune system contributing to higher incidence and severity of many infectious diseases. Particularly within the T cell compartment latent infection with human Cytomegalovirus (CMV) is contributing to and accelerating immunosenescence. However, latent CMV infection and reactivation usually does not cause overt symptoms in immunocompetent elderly persons indicating immunological control of disease.
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