Bandelt,H.J.; Parson,W.; In forensic science, as well as in molecular anthropology and medical genetics, human mitochondrial DNA (mtDNA) variation is being recorded by aligning mtDNA sequences to the revised Cambridge reference sequence (rCRS). This task is straightforward for the vast majority of nucleotide positions but appears to be difficult for some short sequence stretches, namely, in regions displaying length variation. Earlier guidelines for imposing a unique alignment relied on binary alignment to a standard sequence (the rCRS) and used additional priority rules for resolving ambiguities. [Read More]

Lao,O.; Lu,T.T.; Nothnagel,M.; Junge,O.; Freitag-Wolf,S.; Caliebe,A.; Balascakova,M.; Bertranpetit,J.; Bindoff,L.A.; Comas,D.; Holmlund,G.; Kouvatsi,A.; Macek,M.; Mollet,I.; Parson,W.; Palo,J.; Ploski,R.; Sajantila,A.; Tagliabracci,A.; Gether,U.; Werge,T.; Rivadeneira,F.; Hofman,A.; Uitterlinden,A.G.; Gieger,C.; Wichmann,H.E.; Ruther,A.; Schreiber,S.; Becker,C.; Nurnberg,P.; Nelson,M.R.; Krawczak,M.; Kayser,M.; Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. [Read More]

Berger,B.; Eichmann,C.; Parson,W.;

• 2008*

Sanchez,J.J.; Borsting,C.; Balogh,K.; Berger,B.; Bogus,M.; Butler,J.M.; Carracedo,A.; Court DS; Dixon,L.A.; Filipovic,B.; Fondevila,M.; Gill,P.; Harrison,C.D.; Hohoff,C.; Huel,R.; Ludes,B.; Parson,W.; Parsons,T.J.; Petkovski,E.; Phillips,C.; Schmitter,H.; Schneider,P.M.; Vallone,P.M.; Morling,N.; We report the results of an inter-laboratory exercise on typing of autosomal single nucleotide polymorphisms (SNP) for forensic genetic investigations in crime cases. The European DNA Profiling Group (EDNAP), a working group under the International Society for Forensic Genetics (ISFG), organised the exercise. A total of 11 European and one US forensic genetic laboratories tested a subset of a 52 SNP-multiplex PCR kit developed by the SNPforID consortium. [Read More]

Rabl,W.;

• 2008*