Making Waves: Collaboration in the time of SARS-CoV-2 - rapid development of an international co-operation and wastewater surveillance database to support public health decision-making

Lundy,L.; Fatta-Kassinos,D.; Slobodnik,J.; Karaolia,P.; Cirka,L.; Kreuzinger,N.; Castiglioni,S.; Bijlsma,L.; Dulio,V.; Deviller,G.; Lai,F.Y.; Alygizakis,N.; Barneo,M.; Baz-Lomba,J.A.; Been,F.; Cichova,M.; Conde-Perez,K.; Covaci,A.; Donner,E.; Ficek,A.; Hassard,F.; Hedstrom,A.; Hernandez,F.; Janska,V.; Jellison,K.; Hofman,J.; Hill,K.; Hong,P.Y.; Kasprzyk-Hordern,B.; Kolarevic,S.; Krahulec,J.; Lambropoulou,D.; deLlanos,R.; Mackulak,T.; Martinez-Garcia,L.; Martinez,F.; Medema,G.; Micsinai,A.; Myrmel,M.; Nasser,M.; Niederstätter,H.; Nozal,L.; Oberacher,H.; Ocenaskova,V.; Ogorzaly,L.; Papadopoulos,D.; Peinado,B.; Pitkanen,T.; Poza,M.; Rumbo-Feal,S.; Sanchez,M.B.; Szekely,A.J.; Soltysova,A.; Thomaidis,N.S.; Vallejo,J.; vanNuijs,A.; Ware,V.; Viklander,M.; The presence of SARS-CoV-2 RNA in wastewater was first reported in March 2020. [Read More]

Monitoring drug consumption in Innsbruck during coronavirus disease 2019 (COVID-19) lockdown by wastewater analysis

Reinstadler,V.; Ausweger,V.; Grabher,A.L.; Kreidl,M.; Huber,S.; Grander,J.; Haslacher,S.; Singer,K.; Schlapp-Hackl,M.; Sorg,M.; Erber,H.; Oberacher,H.; The coronavirus disease 2019 (COVID-19) has developed into a serious pandemic with millions of cases diagnosed worldwide. To fight COVID-19 pandemic, over 100 countries instituted either a full or partial lockdown, affecting billions of people. In Tyrol, first lockdown measures were taken on 10 March 2020. On 16 March 2020, a curfew went into force which ended on 1 May 2020. [Read More]

MYC-Mediated Ribosomal Gene Expression Sensitizes Enzalutamide-resistant Prostate Cancer Cells to EP300/CREBBP Inhibitors

Furlan,T.; Kirchmair,A.; Sampson,N.; Puhr,M.; Gruber,M.; Trajanoski,Z.; Santer,F.R.; Parson,W.; Handle,F.; Culig,Z.; Patients with advanced prostate cancer are frequently treated with the antiandrogen enzalutamide. However, resistance eventually develops in virtually all patients, and various mechanisms have been associated with this process. The histone acetyltransferases EP300 and CREBBP are involved in regulation of cellular events in advanced prostate cancer. This study investigated the role of EP300/CREBBP inhibitors in enzalutamide-resistant prostate cancer. EP300/CREBBP inhibitors led to the same inhibition of androgen receptor activity in enzalutamide-resistant and -sensitive cells. [Read More]

Penetration of echinocandins into wound secretion of critically ill patients

Gasperetti,T.; Welte,R.; Oberacher,H.; Marx,J.; Lorenz,I.; Schellongowski,P.; Staudinger,T.; Burgmann,K.; Eller,P.; Santner,T.; Griesmacher,A.; Pfisterer,H.; Eschertzhuber,S.; Aigner,M.; Joannidis,M.; Bellmann,R.; PURPOSE: Wound infections caused by Candida are life-threatening and difficult to treat. Echinocandins are highly effective against Candida species and recommended for treatment of invasive candidiasis. As penetration of echinocandins into wounds is largely unknown, we measured the concentrations of the echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS) in wound secretion (WS) and in plasma of critically ill patients. [Read More]

Pharmacokinetics and Antifungal Activity of Echinocandins in Ascites Fluid of Critically Ill Patients

Welte,R.; Oberacher,H.; Gasperetti,T.; Pfisterer,H.; Griesmacher,A.; Santner,T.; Lass-Flörl,C.; Hörtnagl,C.; Leitner-Rupprich,S.; Aigner,M.; Lorenz,I.; Schmid,S.; Edlinger,M.; Eller,P.; Dankl,D.; Joannidis,M.; Bellmann,R.; The pharmacokinetics and antifungal activity of the echinocandins anidulafungin (AFG), micafungin (MFG), and caspofungin (CAS) were assessed in ascites fluid and plasma of critically ill adults treated for suspected or proven invasive candidiasis. Ascites fluid was obtained from ascites drains or during paracentesis. The antifungal activity of the echinocandins in ascites fluid was assessed by incubation of Candida albicans and Candida glabrata at concentrations of 0. [Read More]