Search, Align and Haplogroup – improved forensic mtDNA analysis via EMPOP

Dür,A.; Huber,N.; Parson,W.

Mitochondrial DNA (mtDNA) databases continue to grow and simultaneously the value of information that can be derived from an mtDNA profile is increased by different population and dispersal studies of humankind. However, especially for forensic purposes, quality must become more important than quantity. Clerical errors, inconsistent nomenclature or an insufficient sequence length (not covering the complete control region) are observed most frequently in submitted datasets, illustrating the absolute need of analytical software tools to maintain standards that are required for forensic databases

Systematic Evaluation of Massively Parallel STR Sequencing in the DNASeqEx Project

Müller,P.; Berger,B.; Bodner,M.; Alonso,A.; Barrio,P.; Martin,P.; Köcher,S.; Roewer,L.; Willuweit,S.; Budowle,B.; DNASEQEX Consortium; Parson,W.

The EU funded DNASeqEx (DNA-STR Massive Sequencing & International Information Exchange) project evaluates current massively parallel sequencing (MPS) technologies in a collaborative manner. The aim of the project is to perform interlaboratory evaluation and comparison of forensically relevant parameters, such as allele calling, sensitivity, reproducibility, and concordance in STR analysis using single source and mixture samples.

Tracing Arawakan Southern Dispersal: Clues from Mitogenome Sequencing of Southern Amerinds

Xavier,C.; Simão,F.; Bodner,M.; Strobl,C.; Silva,D.; Barletta,C.; Casas-Vargas,A.; Usaquén,W.; Tineo,D.H.; Gusmão,L.; Parson,W.

South America’s colonization and internal migration routes remain unsolved issues for the scientiic community. The wide variety of different environmental settings and the amplitude of climate variations at the time of colonization might explain the big variation of different tribes and groups in South America, in contrast to it’s northern counterpart.

Y-chromosomal composition of mediaeval and contemporary populations in Norway and adjacent Scandinavian countries: Y-STR haplotypes and the rare Y-haplogroup Q

Berger,B.; Willuweit,S.; Niederstätter,H.; Kralj,P.; Roewer,L.; Hamre,S.; Parson,W.

The project “Immigration and mobility in mediaeval and post-mediaeval Norway” is an international multidisciplinary research collaboration and is part of the Norwegian Research Council ́s ten-year research programme “SAMKUL” (Cultural conditions underlying social change). It aims to combine historical information with archeological, osteological, isotopic and genetic data obtained from medieval (Norway-M) and post-medieval (Norway-PM) skeletal remains excavated in Trondheim, one of the medieval capitals of Norway.

Comparison of CEDIA Buprenorphine II Assay vs. on Market CEDIA Buprenorphine Assay in Human Urine

Buprenorphine is a semi-synthetic opioid derived from the opioid alkaloid thebaine. It is widely used clinically as an analgesic and as a substitute therapy for opioid dependence. It is considered a relatively safe opioid because of its agonistic-antagonistic characteristics on opiate receptors Correlation between dose and therapeutic effects are not linear, indicating a ceiling on the effects in patients.