Xavier,C.; Eduardoff,M.; Strobl,C.; Parson,W.; Measuring the quantity of DNA present in a forensic sample is relevant in a number of ways. First, it informs the analyst about the general DNA content to adjust the volume of DNA extract used for the genotyping assay to the optimal conditions (when possible). Second, quantification values can serve as plausibility checks for the performance of the DNA extraction method used as extraction positive and negative controls demand expected values. [Read More]

Bohn,J.P.; Willenbacher,W.; Peschel,I.; Oberacher,H.; Steurer,M.;

Leuk Lymphoma 2019 60:550-552
PubMed: 30032690

DePicker,L.; Ottoy,J.; Verhaeghe,J.; Deleye,S.; Wyffels,L.; Fransen,E.; Kosten,L.; Sabbe,B.; Coppens,V.; Timmers,M.; deBoer,P.; VanNueten,L.; OpDeBeeck,K.; Oberacher,H.; Vanhoenacker,F.; Ceyssens,S.; Stroobants,S.; Staelens,S.; Morrens,M.; OBJECTIVE: To determine whether state-associated changes in microglial activity, measured with translocator-protein positron emission tomography (TSPO PET), can be identified in psychosis patients through longitudinal evaluation of their regional tracer uptake over the clinical course from acute psychosis to post-treatment follow-up, and comparison to healthy controls. We also evaluated the relation between tracer uptake, clinical symptoms and peripheral immunological markers. [Read More]

Simao,F.; Strobl,C.; Vullo,C.; Catelli,L.; Machado,P.; Huber,N.; Schnaller,L.; Huber,G.; Xavier,C.; Carvalho,E.F.; Gusmao,L.; Parson,W.; Most studies on maternal lineages of South America populations are restricted to control region (CR) markers and, for some geographical regions, the number of studied samples does not adequately represent the existing diversity. This is the case of mitochondrial DNA (mtDNA) studies on Paraguay that are limited to two Native ethnic groups. To overcome this deficiency, we analysed the mitogenomes from 105 individuals living in Alto Parana, the second most populated department of the country. [Read More]

Wieser,V.; Tsibulak,I.; Degasper,C.; Welponer,H.; Leitner,K.; Parson,W.; Zeimet,A.G.; Marth,C.; Fiegl,H.; Inflammation plays a crucial role in the pathogenesis of cancer with tumor necrosis factor-alpha (TNF-alpha) as a key mediator. Recently, spermatogenesis-associated protein 2 (SPATA2) was identified as a TNF receptor modulator which is required for TNF-induced inflammation and apoptosis. The available data on TNF-alpha in ovarian cancer (OC) are inconsistent, and SPATA2 is completely uncharacterized in tumorigenesis. We analyzed expression of SPATA2 and TNFA by quantitative real-time polymerase chain reaction in tissues of 171 patients with low-grade serous (LGSOC), high-grade serous (HGSOC), endometrioid and clear cell OC compared with 28 non-malignant control tissues. [Read More]